Operating through a consortium-based model, the S&T Clusters serve as hubs for innovation, interdisciplinary partnerships, and technology translation, enabling solutions that address critical local and national issues. Structured as a three-tiered pyramid, the Clusters focus on building strong institutional networks at the base, solving regional problems through collaborative actions at the middle tier, and driving national and global competitiveness through impactful technologies at the top.

Currently, there are eight active Clusters across India: Bengaluru Science and Technology Cluster (BeST), Bhubaneshwar City Knowledge Innovation Cluster Foundation (BCKIC), Northern Region S&T Cluster, Chandigarh (PI-RAHI), Delhi Research, Implementation, and Innovation Cluster (DRIIV), Research and Innovation Circle of Hyderabad (RICH), Jodhpur City Knowledge and Innovation Foundation (JCKIF), Pune Knowledge Cluster (PKC), and Vizag Cluster (AMTZ). These Clusters across India are catalyzing innovation in diverse sectors, including healthtech, smart agriculture, environmental sustainability, and industrial automation.

Some of the notable outcomes of the Clusters include the facilitation of EV charging infrastructure in Delhi/NCR, the launch of AR/VR-enabled artisan marketplace “Kalaanubhav.in, and the “One Delhi digital transit app with over 3 lakh users. Health-tech innovations like diabetic foot screening foot-mats, One Health initiatives, waterbody rejuvenation efforts, e-waste management systems, and the development of pacemaker leads at AMTZ Vizag further demonstrate the scalable, high-impact nature of these collaborative solutions.